StemMACS?IWR-1-endoisapotentinhibitoroftheWntsignalingpathway.Itst
ABIlizestheAxin-scaffoldeddestructioncomplex,therebypromotingβ-cateninphosphorylationanddegradation.IncellculturereporterassaysIWR-1-endoinhibitsWnt/β-cateninsignalingwithanIC50valueof180nM.